I. E. Raschip, L. Moldovan, L. Stefan, A. Oancea, C. Vasile

Compatibility and cytotoxicity testing of some new biomaterials based on polyurethane and hydroxypropylcellulose blends

Optoelectronics and Advanced Materials - Rapid Communications 3 (2009) 1336-1342

The aim of the present paper is to study the compatibility and biocompatibility of new polyester urethane with hydroxypropylcellulose (HPC) blends by FT-IR spectroscopy, contact angle measurements. It has been established on the basis of the results obtained and specific interactions that the optima compatibility compositions which assure the good properties of biomaterials is 60% HPC-20% HPC/40% PU-80% PU. The biocompatibility and cytotoxicity of novel materials has been also assessed. The biological analysis showed that the new blends present a good biocompatibility, fibroblast cells cultured in the presence of polymers maintaining their normal cellular phenotype. The obtained blends are not cytotoxic and exhibits good surface properties and could be candidates for medical and pharmaceutical applications.

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