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Viktor A. Ponomarev, Aleksander N. Sheveyko, Elizaveta S. Permyakova, Jihyung Lee, Andrey A. Voevodin, Diana Berman, Anton M. Manakhov, Miroslav Michlíček, Pavel V. Slukin, Viktoriya V. Firstova, Sergey G. Ignatov, Ilya V. Chepkasov, Zakhar I. Popov, Dmitry V. Shtansky

TiCaPCON-Supported Pt- and Fe-Based Nanoparticles and Related Antibacterial Activity

ACS Applied Materials & Interfaces 11 (2019) 28699

A rapid increase in the number of antibiotic-resistant bacteriaurgently requires the development of new more effective yet safe materials tofight infection. Herein, we uncovered the contribution of different metalnanoparticles (NPs) (Pt, Fe, and their combination) homogeneouslydistributed over the surface of nanostructured TiCaPCONfilms in the totalantibacterial activity toward eight types of clinically isolated bacterial strains (Escherichia coliK261,Klebsiella pneumoniaeB1079k/17-3,AcinetobacterbaumanniiB1280A/17,Staphylococcus aureusno. 839,Staphylococcusepidermidisi5189-1,Enterococcus faeciumYa-235: VanA,E. faeciumI-237: VanA, andE. coliU20) taking into account variousfactors that can affect bacterial mechanisms: surface chemistry and phase composition, wettability, ion release, generation ofreactive oxygen species (ROS), potential difference and polarity change between NPs and the surrounding matrix, formation ofmicrogalvanic couples on the sample surfaces, and contribution of a passive oxide layer, formed on the surface offilms, togeneral kinetics of the NP dissolution. The results indicated that metal ion implantation and subsequent annealing significantlychanged the chemistry of the TiCaPCONfilm surface. This, in turn, greatly affected the shedding of ions, ROS formation,potential difference betweenfilm components, and antibacterial activity. The presence of NPs was critical for ROS generationunder UV or daylight irradiation. By eliminating the potential contribution of ions and ROS, we have shown that bacteria can bekilled using direct microgalvanic interactions. The possibility of charge redistribution at the interfaces between Pt NPs and TiO2(anatase and rutile), TiC, TiN, and TiCN components was demonstrated using density functional theory calculations. TheTiCaPCON-supported Pt and Fe NPs were not toxic for lymphocytes and had no effect on the ability of lymphocytes toactivate in response to a mitogen. This study provides new insights into understanding and designing of antibacterial yetbiologically safe surfaces.

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DOI: 10.1021/acsami.9b09649

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